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Curr Opin Microbiol. 2006 Feb;9(1):55-61. Epub 2006 Jan 18.

Yersinia's stratagem: targeting innate and adaptive immune defense.

Author information

1
Max von Pettenkofer-Institut, Pettenkoferstrasse 9 a, D-80336 Muenchen, Germany. Heesemann@m3401.mpk.med.uni-muenchen.de

Abstract

In contrast to Salmonella and Shigella, enteropathogenic Yersinia species are extracellular multiplying Gram-negative bacteria. This life style requires a sophisticated anti-host strategy, which is implemented by the Yersinia virulence plasmid. This plasmid encodes the type 3 secretion system (injectisome), at least six microinjected anti-host effector proteins, a trimeric coiled coil outer membrane protein (Yersinia adhesin) with cell adhesin and protective functions against complement and defensins, and the released V antigen, which has Toll-like receptor 2 agonist activity.

PMID:
16413818
DOI:
10.1016/j.mib.2005.10.018
[Indexed for MEDLINE]
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