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Cell. 2006 Jan 13;124(1):27-34.

Lingering mysteries of ubiquitin-chain assembly.

Author information

1
Yale University, Department of Molecular Biophysics & Biochemistry, New Haven, CT 06520, USA. mark.hochstrasser@yale.edu

Abstract

The small protein ubiquitin is often linked to substrates as a polymer. Such polymers vary in both linkage and length, which has important consequences for their function. Surprisingly, the mechanisms of ubiquitin-chain assembly are still not known. Deciphering them will shed light on why substrates differ in the extent and timing of polyubiquitin modification and how ancillary ubiquitination factors function.

PMID:
16413479
DOI:
10.1016/j.cell.2005.12.025
[Indexed for MEDLINE]
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