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Cell. 2006 Jan 13;124(1):15-7.

Pathogens reWritE Rho's rules.

Author information

1
University of Cambridge, Department of Pathology, Cambridge CB2 1QP, UK.

Abstract

Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.

PMID:
16413475
DOI:
10.1016/j.cell.2005.12.024
[Indexed for MEDLINE]
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