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Bioorg Med Chem Lett. 2006 Mar 15;16(6):1514-7. Epub 2006 Jan 18.

Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents.

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  • 1Department of Chemistry, University of Pune, Pune 411 007, India.


Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and (1)H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.

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