Format

Send to

Choose Destination
Cancer Biol Ther. 2006 Feb;5(2):225-7. Epub 2006 Feb 20.

Detection of BRAF gene mutation in primary choroidal melanoma tissue.

Author information

1
Department of Biomedical Sciences, Vittorio Emanuele II Hospital, Catania, Italy.

Abstract

Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. In contrast, several studies report lack of BRAF mutations in uveal melanoma including primary and metastatic choroidal and ciliary body melanomas. To our knowledge, for the first time, here we report a case of choroidal melanoma harboring the BRAF mutation (V600E). The activation of RAF/MEK/ERK pathway, although independent of BRAF mutation, was reported in uveal melanoma. The presence of V600E mutation indicates that the RAF/MEK/ERK pathway, in addition to cutaneous melanoma progression, may play a role in the choroidal melanoma development.

PMID:
16410717
DOI:
10.4161/cbt.5.2.2429
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center