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Nature. 1992 Jul 23;358(6384):302-7.

The folding of hen lysozyme involves partially structured intermediates and multiple pathways.

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1
Oxford Centre for Molecular Sciences, University of Oxford, UK.

Abstract

Analysis of the folding of hen lysozyme shows that the protein does not become organized in a single cooperative event but that different parts of the structure become stabilized with very different kinetics. In particular, in most molecules the alpha-helical domain folds faster than the beta-sheet domain. Furthermore, different populations of molecules fold by kinetically distinct pathways. Thus, folding is not a simple sequential assembly process but involves parallel alternative pathways, some of which may involve substantial reorganization steps.

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PMID:
1641003
DOI:
10.1038/358302a0
[Indexed for MEDLINE]
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