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Nat Chem Biol. 2006 Jan;2(1):29-30. Epub 2005 Nov 20.

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

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  • 1Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

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PMID:
16408088
DOI:
10.1038/nchembio753
[PubMed - indexed for MEDLINE]
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