Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Physiol. 2006 Mar;91(2):307-21. Epub 2006 Jan 11.

Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models.

Author information

1
The Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. peter.kohl@physiol.ox.ac.uk

Abstract

The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.

PMID:
16407474
DOI:
10.1113/expphysiol.2005.031062
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center