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Drug Resist Updat. 2005 Dec;8(6):359-68. Epub 2006 Jan 6.

Altering protein turnover in tumor cells: new opportunities for anti-cancer therapies.

Author information

1
LNICB, Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, Pardiciano 99, 34100 Trieste, Italy.

Abstract

The promising effects of the proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of certain types of cancer have fired up the interest on this multicatalytic proteolytic machinery. A number of recent reviews thoroughly describe various aspects of the ubiquitin-proteasome system and its importance in the control of cell growth and tumorigenesis. Here, we will focus on recent data unveiling a link between the proteasome and some elements of the apoptotic machinery including Bcl-2 members, caspases, IAPs and IAP antagonists. Perturbing their turnover significantly contributes to the apoptotic response and the anti-neoplastic activity of proteasome inhibitors.

PMID:
16406769
DOI:
10.1016/j.drup.2005.12.001
[Indexed for MEDLINE]

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