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Ann Neurol. 2006 Feb;59(2):335-43.

Functional connectivity networks are disrupted in left temporal lobe epilepsy.

Author information

1
Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia.

Abstract

OBJECTIVE:

Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions.

METHODS:

We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls.

RESULTS:

Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps.

INTERPRETATION:

We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.

PMID:
16404743
DOI:
10.1002/ana.20733
[Indexed for MEDLINE]

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