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J Pediatr. 1992 Aug;121(2):299-303.

Randomized, controlled trial of antibiotic therapy for Escherichia coli O157:H7 enteritis.

Author information

1
Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Québec, Canada.

Abstract

We undertook a prospective, controlled study to evaluate the effect of trimethoprim-sulfamethoxazole in children with proven Escherichia coli O157:H7 enteritis on the duration fo symptoms, on fecal excretion of pathogen, and on the risk of progression to hemolytic-uremic syndrome. There was no statistically significant effect of treatment on progression of symptoms, fecal pathogen excretion, or the incidence of HUS (2/22 vs 4/25; p = 0.67). Our results suggest that a multicentric trial using rapid diagnostic methods to permit early randomization should be carried out.

PMID:
1640303
DOI:
10.1016/s0022-3476(05)81209-0
[Indexed for MEDLINE]

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