Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur Heart J. 2006 Jun;27(11):1282-8. Epub 2006 Jan 9.

Impact of age and gender on in-hospital and late mortality after acute myocardial infarction: increased early risk in younger women: results from the French nation-wide USIC registries.

Author information

1
Department of Pharmacology, Saint-Antoine, Pierre et Marie Curie University, 27 Rue Chaligny, 75012 AP-HP, and Department of Cardiology, Hôpital Européen Georges Pompidou, Paris, France. tabassome.simon@chusa.jussieu.fr

Abstract

AIMS:

To determine whether sex differences of in-hospital and after-discharge mortality differ according to the age.

METHODS AND RESULTS:

Data of 4347 consecutive patients hospitalized within 48 h of the onset of acute myocardial infarction (AMI) were analysed. Patients were classified according to median age (68 years): Group 1 (G1) (308 women, 30-67 years), G2 (1878 men, 30-67 years), G3 (860 women, 68-89 years), and G4 (1301 men, 68-89 years). In both age groups, women were older, had more frequent co-morbidities, lower rate of reperfusion therapy, and received less anti-platelet agents, beta-blockers, and statins than men. The overall 1-year mortality was higher in women (25% vs. 16% in men, P<0.0001). After adjustment, in-hospital mortality was higher only for the women in the younger age group. (G1 vs. G2: OR=2.2, 95%CI=1.3-3.8; G3 vs. G4: OR=1.1, 95%CI=the risk of death, after hospital discharge, was no longer related to gender in any age group.

CONCLUSION:

The higher 1-year mortality following AMI in women is explained by the higher risk of death in young women during the first days of hospitalization. Further investigations are crucial to determine the cause in order to improve the chance of survival in younger women.

PMID:
16401671
DOI:
10.1093/eurheartj/ehi719
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center