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CNS Spectr. 2005 Oct;10(10):831-9.

Emotional learning and glutamate: translational perspectives.

Author information

1
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA.

Abstract

Anxiety disorders are a common focus of clinical concern and certain forms of anxiety may be conceptualized as disorders of emotional learning. Behavior therapies effective in the treatment of anxiety are modeled on extinction training as a means of reducing pathological anxiety. The present understanding of human anxiety has been informed by preclinical research using rodent models to study the acquisition and extinction of fear. Glutamate appears to have a central role in both of these processes. The authors review this literature and discuss novel applications of D-cycloserine, a partial N-methyl-D-aspartate agonist, for the treatment of anxiety.

PMID:
16400246
PMCID:
PMC2764739
[Indexed for MEDLINE]
Free PMC Article

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