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Dev Cell. 2006 Jan;10(1):11-20.

Mechanisms of mechanotransduction.

Author information

1
Cardiovascular Research Center, University of Virginia, 415 Lane Road, Charlottesville, Virginia 22908, USA.

Erratum in

  • Dev Cell. 2006 Mar;10(3):407.

Abstract

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.

PMID:
16399074
DOI:
10.1016/j.devcel.2005.12.006
[Indexed for MEDLINE]
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