Format

Send to

Choose Destination
Cell Death Differ. 2006 May;13(5):843-51.

NF-kappaB-related genetic diseases.

Author information

1
INSERM U697, Pavillon Bazin, Hôpital Saint-Louis, Paris, France. gilles.courtois@stlouis.inserm.fr

Abstract

The recent identification of genetic diseases (incontinentia pigmenti, anhidrotic ectodermal dysplasia with immunodeficiency and cylindromatosis) resulting from mutations affecting components of the nuclear factor-kappaB (NF-kappaB) signaling pathway provides a unique opportunity to understand the function of NF-kappaB in vivo. Besides confirming the importance of NF-kappaB in innate and acquired immunity or bone mass control, analysis of these diseases has uncovered new critical roles played by this transcription factor in the development and homeostasis of the epidermis and the proper function of lymphatic vessels. In addition, the identified mutations will help understanding at the molecular level how NF-kappaB is activated in response to cell stimulation.

PMID:
16397577
DOI:
10.1038/sj.cdd.4401841
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center