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Nat Rev Cancer. 2006 Jan;6(1):52-62.

A PANorama of PAX genes in cancer and development.

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1
Department of Pathology, University of Otago, PO Box 913, Dunedin 9001, New Zealand.

Abstract

Populations of self-renewing cells that arise during normal embryonic development harbour the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour generation. So, control mechanisms are essential to prevent rapidly expanding populations from malignant growth. Transcription factors have crucial roles in ensuring establishment of such regulation, with the Pax gene family prominent amongst these. This review examines the role of Pax family members during embryogenesis, and their contribution to tumorigenesis when subverted.

PMID:
16397527
DOI:
10.1038/nrc1778
[Indexed for MEDLINE]
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