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J Clin Invest. 2006 Jan;116(1):209-16.

Soy diet worsens heart disease in mice.

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  • 1Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado, USA.

Abstract

We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the alpha-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta (GSK3beta), and caspase-3 activation.

PMID:
16395406
PMCID:
PMC1323247
DOI:
10.1172/JCI24676
[PubMed - indexed for MEDLINE]
Free PMC Article
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