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Curr Dir Autoimmun. 2006;9:162-72.

MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure.

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1
Department of Genetics, Osaka University Medical School, Osaka, Japan.

Abstract

Apoptotic cells are swiftly engulfed by macrophages and immature dendritic cells. Inefficient clearance of apoptotic cells has been implicated as a cause of inflammation and autoimmune diseases. Milk fat globule-EGF factor 8 (MFG-E8) and developmental endothelial locus-1 (Del-1) are glycoproteins secreted from macrophages that pass apoptotic cells to phagocytes. MFG-E8, but not Del-1, is expressed in the tingible-body macrophages at the germinal centers of the second lymphoid tissues. MFG-E8-deficient mice carry many unengulfed apoptotic cells in the germinal centers of the spleen, and develop a lupus-like autoimmune disease. In this review, we discuss the importance of the MFG-E8-mediated clearance of apoptotic cells in the prevention of autoimmune diseases.

PMID:
16394660
DOI:
10.1159/000090780
[Indexed for MEDLINE]
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