Format

Send to

Choose Destination
J Hered. 2006 Jan-Feb;97(1):62-6. Epub 2006 Jan 4.

An algorithm for analyzing linkages affected by heterozygous translocations: QuadMap.

Author information

1
Department of Plant and Animal Sciences, 275 WIDB, Brigham Young University, Provo, UT 84602, USA.

Abstract

Heterozygous chromosome rearrangements such as reciprocal translocations are most accurately displayed as two-dimensional linkage maps. Standard linkage mapping software packages, such as MapMaker, generate only one-dimensional maps and so reciprocal translocations appear as clusters of markers, even though they originate from two nonhomologous chromosomes. To more accurately map these regions, researchers have developed statistical methods that use the variance in map distance to distinguish among the four segments (two translocation, two interstitial) of the translocation. In this study, we describe modifications to one of these protocols, that proposed by Livingstone et al. (2000). We also introduce QuadMap, a new software application for dissecting heterozygous translocation-affected linkage maps.

PMID:
16394257
DOI:
10.1093/jhered/esj002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center