Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population

Int J Neurosci. 2006 Feb;116(2):157-64. doi: 10.1080/00207450341514.

Abstract

KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Reference Values
  • Schizophrenia / genetics*
  • Small-Conductance Calcium-Activated Potassium Channels / genetics*
  • Statistics, Nonparametric
  • Trinucleotide Repeats / genetics*
  • Yugoslavia

Substances

  • KCNN3 protein, human
  • Small-Conductance Calcium-Activated Potassium Channels