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Eur J Clin Nutr. 2006 May;60(5):605-9.

Effect of vitamin D and calcium supplementation on bone turnover in institutionalized adults with Down's Syndrome.

Author information

1
Fundacion Uliazpi, Portu-Etxe 53, 20018 San Sebastián, Gipuzkoa, Spain. pzubillaga@telefonica.net

Abstract

OBJECTIVE:

To assess the status of vitamin D and the effects of calcium and vitamin D3 supplementation on the bone metabolism in a group of adults with Down's syndrome (DS).

DESIGN:

Randomized, parallel, controlled and open clinical trial.

SETTING:

Institution for mentally handicapped: Fundación Uliazpi, Diputación Foral de Guipúzcoa, San Sebastián, Spain.

SUBJECTS:

A total of 23 persons with DS, residents at the Uliazpi Foundation were recruited and all completed the study.

INTERVENTION:

In all, 12 participants were randomly allocated to receive 1 g of calcium and 800 IU of vitamin D once daily for 1 year while 11 were assigned to the control group, receiving no supplementation.

RESULTS:

We found no differences between groups regarding serum calcium and phosphorous levels. The remaining parameters showed differences between the two groups consistent with a beneficial effect of the intervention: serum levels of parathyroid hormone, osteocalcin and crosslaps diminished while serum 25 OH vitamin D3 level increased.

CONCLUSIONS:

The results obtained allow to include people with DS as a risk group with regards to vitamin D deficit, which that can be corrected with vitamin D and calcium supplementation, and giving rise to an improvement of the biochemical markers related to the phospho-calcium metabolism and bone remodelling.

PMID:
16391575
DOI:
10.1038/sj.ejcn.1602357
[Indexed for MEDLINE]
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