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EMBO Rep. 2006 Jan;7(1):41-5.

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.

Author information

1
Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne, France.

Abstract

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.

PMID:
16391536
PMCID:
PMC1369233
DOI:
10.1038/sj.embor.7400598
[Indexed for MEDLINE]
Free PMC Article

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