Format

Send to

Choose Destination
J Exp Med. 2006 Jan 23;203(1):141-52. Epub 2006 Jan 3.

Identification of the target self-antigens in reperfusion injury.

Author information

1
CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.

Abstract

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

PMID:
16390934
PMCID:
PMC2118091
DOI:
10.1084/jem.20050390
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center