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J Matern Fetal Neonatal Med. 2005 Nov;18(5):289-98.

Perinatal and neurodevelopmental outcome with isolated fetal ventriculomegaly: a systematic review.

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  • 1Department of Obstetrics & Gynecology, Mount Sinai Hospital, University of Toronto, Canada.

Abstract

OBJECTIVE:

To establish the perinatal and neurodevelopmental outcomes of fetuses diagnosed with isolated ventriculomegaly (IVM).

METHODS:

A systematic review of cohort, case/control studies, case series and case reports of IVM (unilateral or bilateral enlargement of the lateral ventricle, >or=10 mm, with no additional diagnosis at the time of the initial ultrasound), identified by searching, without language restrictions, The Cochrane Library, MEDLINE and Embase databases in June 2004.

RESULTS:

No cohort study was retrieved but 577 cases were identified in one case/control study and 29 case series/case reports. Of 207 cases with follow-up and known gestational age at diagnosis, normal developmental outcomes were found in 82%, mild impairments in 9% and moderate/severe impairments in 10%. Prenatal diagnosis could possibly have reduced the risk of moderate/severe impairments to 7%. In 137 cases followed to at least 20 months of age, 79% had normal neurodevelopment, 10% were mildly delayed and 11% had moderate/severe developmental delays.

CONCLUSIONS:

Outcome was favorable in 85% of IVM cases, decreasing to 79% when cases were followed to at least 20 months of age. We recommend prospective cohort studies with new diagnostic modalities to better identify the underlying conditions relating to moderate/severe impairments in the remaining cases.

PMID:
16390787
DOI:
10.1080/14767050500329775
[PubMed - indexed for MEDLINE]
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