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J Obstet Gynaecol. 2006 Jan;26(1):11-4.

Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight.

Author information

1
Department of Feto-Maternal Medicine, Leeds General Infirmary, and Academic Department of Obstetrics and Gynaecology, St James University Teaching Hospital, UK. tracey.glanville@leedsth.nhs.uk

Abstract

The aim of this study was to determine if fetal C677T methylenetetrahydrofolate reductase (MTHFR) genotype contributes to low birth weight. The study group consisted of 243 term babies with a birth weight<10th centile for gestational age, with subgroup analyses for those <1st centile. The control group consisted of 132 term babies with a birth weight 3.3-3.8 kg. Odds ratio analyses with 95% confidence intervals (CI) were calculated for carriage of the t allele and overall genotype frequencies. There was no significant difference in carriage of the t allele between study and control groups, odds ratio (OR) 0.79 (95% CI, 0.57-1.09). No differences were observed for frequencies of heterozygote and recessive homozygote genotypes for the two populations. In the subgroup analyses, no statistical differences were observed in the t allele frequency, frequency of the heterozygote or homozygote genotype. Trends were seen and the study suggests that fetal C677T MTHFR genotype may be a factor contributing to birth weight. The potential may exist to influence clinical outcome by maternal folate supplementation.

PMID:
16390701
DOI:
10.1080/01443610500363865
[Indexed for MEDLINE]

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