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Br J Clin Pharmacol. 2006 Jan;61(1):101-4.

Quantification of infant exposure to celecoxib through breast milk.

Author information

1
Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand. sharon.gardiner@cdhb.govt.nz

Abstract

AIMS:

To determine the milk-to-plasma (M/P) concentration ratio of celecoxib, and estimate likely infant exposure.

METHODS:

Blood and milk were sampled for 48 h after oral administration of celecoxib 200 mg to six lactating volunteers. The M/P ratio was derived from the area under the concentration-time curves (0-infinity) and the infant 'dose' estimated from celecoxib concentrations in milk.

RESULTS:

The median (range) M/P ratio was 0.18 (0.15-0.26). The median (range) infant 'dose' was 0.23% (0.17-0.30%) of the maternal dose, adjusted for weight.

CONCLUSION:

The relative 'dose' of celecoxib to which infants are exposed via milk is very low, suggesting that breastfeeding during routine dosing would pose minimal risk.

PMID:
16390357
PMCID:
PMC1884977
DOI:
10.1111/j.1365-2125.2005.02520.x
[Indexed for MEDLINE]
Free PMC Article

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