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J Am Chem Soc. 2006 Jan 11;128(1):38-9.

A unimolecular G-quadruplex that functions as a synthetic transmembrane Na+ transporter.

Author information

1
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

Abstract

We describe the covalent post-modification of a hydrogen-bonded assembly with the subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting unimolecular G-quadruplex folds in the environment of a phospholipid membrane and functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport assays.

PMID:
16390110
DOI:
10.1021/ja056888e
[Indexed for MEDLINE]

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