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Contemp Clin Trials. 2006 Jun;27(3):269-73. Epub 2006 Jan 4.

A new method of evaluating antitumor activity from measured tumor volumes.

Author information

1
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 630 Rochester, NY 14642, USA. hliang@bst.rochester.edu

Abstract

In studies of antitumor activity, measurement of tumor growth delay is commonly used to evaluate treatment effects. However, this measurement sometimes provides no information. We propose an approach for comparing tumor response by using nonparametric regression. In a xenograft model, we found that a significant difference between two treatment effects was undetectable by comparison of tumor growth delays. The results of our finding suggest that measurements used to evaluate the treatment effects should be carefully selected in analyses of antitumor activity.

PMID:
16388989
DOI:
10.1016/j.cct.2005.11.004
[Indexed for MEDLINE]
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