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Genetics. 2006 Mar;172(3):2011-4. Epub 2005 Dec 30.

Positive selection can create false hotspots of recombination.

Author information

1
Department of Biology, University of Maryland, College Park, Maryland 20742, USA. freed@umd.edu

Abstract

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

PMID:
16387873
PMCID:
PMC1456281
DOI:
10.1534/genetics.105.052183
[Indexed for MEDLINE]
Free PMC Article

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