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Am J Respir Crit Care Med. 2006 Mar 15;173(6):617-22. Epub 2005 Dec 30.

Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity.

Author information

1
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia. andrew.martin@health.wa.gov.au

Abstract

RATIONALE:

The majority of previous studies investigating asthma genetics have focused on cohorts with stable disease and have not defined mechanisms important during acute asthma. CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region polymorphism.

OBJECTIVES:

This study was designed to determine the influence of these polymorphisms on plasma levels of their products and clinical disease during acute asthma. We hypothesized that genotype-related differences in CD14 and CC16 production would be more marked during acute asthma and related to disease severity.

METHODS:

We studied 148 children on presentation with acute asthma and again in convalescence. CD14 C-159T and CC16 A38G genotypes were determined, and plasma levels of soluble CD14 (sCD14) and CC16 were measured at both times.

MEASUREMENTS AND MAIN RESULTS:

During acute asthma, plasma sCD14 levels were higher for the whole group (p = 0.003), but increases were only in subjects with CD14 -159TT (p = 0.003) and -159CT (p = 0.004), and not in those with -159CC. Plasma CC16 levels were also elevated acutely for the whole group (p = 0.013), but only in those with CC16 38GG (p = 0.043) and 38AG (p = 0.014), and not in those with CC16 38AA. Subjects with CD14 -159CC and CC16 38AA were more likely to have moderate or severe acute asthma.

CONCLUSIONS:

Plasma levels of sCD14 and CC16 were higher during acute asthma in the subjects. Those with CD14 -159CC and CC16 38AA had no change in sCD14 and CC16 levels and more severe asthma.

PMID:
16387800
DOI:
10.1164/rccm.200509-1367OC
[Indexed for MEDLINE]

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