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Bioorg Med Chem Lett. 2006 Mar 15;16(6):1477-80. Epub 2006 Jan 4.

Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

Author information

1
Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. andrew_jennings@merck.com

Abstract

Imidazo[1,2-a]pyrimidines and imidazo[1,2-b][1,2,4]triazines are ligands for the benzodiazepine binding site of GABA(A) receptors that are functionally selective for the alpha2/alpha3 subtypes over the alpha1 subtype. SAR studies to optimise this functional selectivity, pharmacokinetic and behavioural data are described.

PMID:
16386900
DOI:
10.1016/j.bmcl.2005.12.044
[Indexed for MEDLINE]

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