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FEBS Lett. 2006 Jan 23;580(2):497-504. Epub 2005 Dec 22.

Decreased blood pressure in NOX1-deficient mice.

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Department of Rehabilitation and Geriatrics, Geneva Medical Faculty, 1211 Geneva 4, Switzerland.


To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOX1-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved, but there was a marked decrease in extracellular matrix accumulation. Our results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response.

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