Format

Send to

Choose Destination
See comment in PubMed Commons below
J Bacteriol. 2006 Jan;188(2):815-9.

The quorum-sensing negative regulator RsaL of Pseudomonas aeruginosa binds to the lasI promoter.

Author information

1
Department of Biology, University Roma Tre, Viale G. Marconi 446, 00146, Rome, Italy.

Abstract

A mutation in the rsaL gene of Pseudomonas aeruginosa produces dramatically higher amounts of N-acyl homoserine lactone with respect to the wild type, highlighting the key role of this negative regulator in controlling quorum sensing (QS) in this opportunistic pathogen. The DNA binding site of the RsaL protein on the rsaL-lasI bidirectional promoter partially overlaps the binding site of the LasR protein, consistent with the hypothesis that RsaL and LasR could be in binding competition on this promoter. This is the first direct demonstration that RsaL acts as a QS negative regulator by binding to the lasI promoter.

PMID:
16385073
PMCID:
PMC1347304
DOI:
10.1128/JB.188.2.815-819.2006
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center