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Cancer Genet Cytogenet. 1992 Jul 15;61(2):193-6.

Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma.

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1
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

Abstract

Although ependymomas comprise 5-10% of pediatric brain tumors, consistent cytogenetic aberrations have not been identified in these neoplasms. We report karyotypes for two ependymomas. A predominantly well-differentiated ependymoma contained several numerical chromosome aberrations, including monosomy 22. In contrast, an anaplastic ependymoma had a more complex karyotype that included loss of one chromosome 22 homologue and a balanced translocation at q13.3 in the remaining 22 homologue. These findings suggest the location of an ependymoma tumor suppressor gene on the long arm of chromosome 22.

PMID:
1638502
DOI:
10.1016/0165-4608(92)90085-m
[Indexed for MEDLINE]

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