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Nucleic Acids Res. 2006 Jan 1;34(Database issue):D213-7.

LOCATE: a mouse protein subcellular localization database.

Author information

1
ARC Centre in Bioinformatics, University of Queensland, St Lucia, Queensland 4072, Australia. l.fink@imb.uq.edu.au

Abstract

We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunofluorescence-based assay and by manually reviewing >1700 peer-reviewed publications. LOCATE represents the first effort to catalogue the experimentally verified subcellular location and membrane organization of mammalian proteins using a high-throughput approach and provides localization data for approximately 40% of the mouse proteome. It is available at http://locate.imb.uq.edu.au.

PMID:
16381849
PMCID:
PMC1347432
DOI:
10.1093/nar/gkj069
[Indexed for MEDLINE]
Free PMC Article

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