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Nucleic Acids Res. 2006 Jan 1;34(Database issue):D199-203.

PPD v1.0--an integrated, web-accessible database of experimentally determined protein pKa values.

Author information

1
Edward Jenner Institute for Vaccine Research Compton, Berkshire, RG20 7NN, UK.

Abstract

The Protein pK(a) Database (PPD) v1.0 provides a compendium of protein residue-specific ionization equilibria (pK(a) values), as collated from the primary literature, in the form of a web-accessible postgreSQL relational database. Ionizable residues play key roles in the molecular mechanisms that underlie many biological phenomena, including protein folding and enzyme catalysis. The PPD serves as a general protein pK(a) archive and as a source of data that allows for the development and improvement of pK(a) prediction systems. The database is accessed through an HTML interface, which offers two fast, efficient search methods: an amino acid-based query and a Basic Local Alignment Search Tool search. Entries also give details of experimental techniques and links to other key databases, such as National Center for Biotechnology Information and the Protein Data Bank, providing the user with considerable background information. The database can be found at the following URL: http://www.jenner.ac.uk/PPD.

PMID:
16381845
PMCID:
PMC1347398
DOI:
10.1093/nar/gkj035
[Indexed for MEDLINE]
Free PMC Article

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