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Curr Opin Genet Dev. 1992 Apr;2(2):227-35.

Myc and Max function as a nucleoprotein complex.

Author information

1
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

Abstract

The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins form sequence-specific DNA-binding complexes with Max, a new member of the helix-loop-helix leucine zipper protein class. The properties of the Myc-Max complex suggest a mechanism for Myc's function in both normal and neoplastic cell behavior.

PMID:
1638116
DOI:
10.1016/s0959-437x(05)80278-3
[Indexed for MEDLINE]

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