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Curr Opin Cell Biol. 2006 Feb;18(1):68-73. Epub 2005 Dec 27.

Walking with myosin V.

Author information

1
Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1762, USA. sellersj@nhlbi.nih.gov

Abstract

The cytoplasm of cells is teaming with vesicles and other cargo that are moving along tracks of microtubules or actin filaments, powered by myosins, kinesins and dyneins. Myosin V has been implicated in several types of intracellular transport. The mechanism by which myosin V moves processively along actin filaments has been the subject of many biophysical and biochemical studies and a consensus is starting to emerge about how this minute molecular motor operates.

PMID:
16378722
DOI:
10.1016/j.ceb.2005.12.014
[Indexed for MEDLINE]

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