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J Steroid Biochem Mol Biol. 1992 Jul;42(6):589-95.

The ontogeny and cellular distribution of estrogen receptors in normal mouse mammary gland.

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Physiology Department, Michigan State University, East Lansing 48824-1101.


The appearance, epithelial and stromal cell distribution of estrogen receptors (ER) in normal mouse mammary gland were determined between 1 and 10 weeks of age using immunohistochemistry. The effect of ovariectomy and estrogen (E)-treatment on the distribution and concentration of ER-positive cells at various ages was also analyzed. These studies demonstrate that ER are present in both mammary epithelial and stromal cells before the mammary gland exhibits a proliferative response or increase in progesterone receptor concentration as a result of E-treatment. Furthermore, an analysis of E-treatment suggests that although ER are present at an early age, there may be additional factors that determine the nature and extent of E-responsiveness.

[Indexed for MEDLINE]

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