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Schizophr Res. 2006 Feb 28;82(2-3):153-62. Epub 2005 Dec 27.

Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia.

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Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA.



Patients with schizophrenia show deficits in facial affect and facial identity recognition and exhibit structural and neurophysiological abnormalities in brain regions known to mediate these processes. Functional neuroimaging studies of neural responses to emotional facial expressions in schizophrenia have reported both increases and decreases in medial temporal lobe (MTL) activity in schizophrenia. Some of this variability may be related to the tasks performed and the baseline conditions used. Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition.


15 patients with schizophrenia and 16 healthy control subjects underwent functional magnetic resonance imaging (fMRI) while passively viewing human faces displaying fearful, happy, and neutral emotional expressions.


Relative to control subjects, the patients demonstrated (1) significantly greater activation of the left hippocampus while viewing all three facial expressions and (2) increased right amygdala activation during the initial presentation of fearful and neutral facial expressions.


In schizophrenia, hippocampal and amygdala activity is elevated during the passive viewing of human faces.

[Indexed for MEDLINE]

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