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Trends Pharmacol Sci. 2006 Feb;27(2):97-104. Epub 2005 Dec 27.

Targeting Rho and Rho-kinase in the treatment of cardiovascular disease.

Author information

1
Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Abstract

The small GTPase Rho and its downstream effector Rho-kinase contribute to agonist-induced vascular contraction via Ca2+ sensitization. Reasonably selective pharmacological inhibitors of these proteins have been developed and are now widely used experimentally to investigate the role of this signaling pathway in vascular function. Rho and Rho-kinase have attracted increasing clinical interest as a result of emerging evidence for their roles in the pathogenesis of several cardiovascular disorders, including hypertension, coronary and cerebral vasospasm, atherosclerosis and diabetes, and are now considered important future therapeutic targets. A major challenge lies in further developing selective inhibitors of this pathway beyond experimental use. Consideration should perhaps also be given to widening the application of existing clinical drugs now known to also interfere with Rho-Rho-kinase signaling.

PMID:
16376997
DOI:
10.1016/j.tips.2005.12.002
[Indexed for MEDLINE]

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