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J Interferon Cytokine Res. 2005 Dec;25(12):745-8.

Unexpected roles for deacetylation in interferon- and cytokine-induced transcription.

Author information

1
Department of Medicine Northwestern University, 2200 Campus Drive, Evanston, IL 60208, USA. Inna-Nusinzon@northwestern.edu

Abstract

Protein acetylation is a reversible modification that has been implicated in epigenetic regulation of gene expression. It is widely accepted that acetylation enzymes are present at transcriptionally active promoters and deacetylation enzymes associate with transcriptionally silent loci. These results notwithstanding, recent findings indicate that positive regulation of gene expression by interferons and other cytokines requires both acetylation and deacetylation.

PMID:
16375602
DOI:
10.1089/jir.2005.25.745
[Indexed for MEDLINE]

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