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Science. 2005 Dec 23;310(5756):1963-6.

Category-specific cortical activity precedes retrieval during memory search.

Author information

1
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. polyn@psych.upenn.edu

Abstract

Here we describe a functional magnetic resonance imaging study of humans engaged in memory search during a free recall task. Patterns of cortical activity associated with the study of three categories of pictures (faces, locations, and objects) were identified by a pattern-classification algorithm. The algorithm was used to track the reappearance of these activity patterns during the recall period. The reappearance of a given category's activity pattern correlates with verbal recalls made from that category and precedes the recall event by several seconds. This result is consistent with the hypothesis that category-specific activity is cueing the memory system to retrieve studied items.

PMID:
16373577
DOI:
10.1126/science.1117645
[Indexed for MEDLINE]
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