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Muscle Nerve. 2006 May;33(5):691-3.

Mass-dependent decline of skeletal muscle function in cancer cachexia.

Author information

1
Numico Research, Department of BioMedical Research, Bosrandweg 20, 6704 PH Wageningen, The Netherlands. Marchel.Gorselik@Numeco-research

Abstract

CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor-bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle "quality" appears unaltered.

PMID:
16372346
DOI:
10.1002/mus.20467
[Indexed for MEDLINE]

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