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Ann Thorac Surg. 2006 Jan;81(1):362-4.

Presentation and management of a stage Ia lung cancer patient with a paraneoplastic factor VIII inhibitor.

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Division of Hematology/Oncology, Northwestern Memorial Hospital, Chicago, Illinois, USA.


Acquired inhibitors to clotting factors most commonly involve factor VIII and are associated with autoimmune disease. Factor VIII inhibitors can cause severe spontaneous and iatrogenic bleeding that is difficult to manage. Factor VIII inhibitors are rarely associated with solid tumors and only three cases of adenocarcinoma of the lung have been reported. This report describes the multidisciplinary management of a factor VIII inhibitor-producing stage Ia lung adenocarcinoma that ultimately resulted in complete resectability.

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