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Vaccine. 2006 Mar 15;24(12):2035-42. Epub 2005 Nov 28.

Diphtheria tetanus pertussis poliomyelitis vaccination and reported atopic disorders in 8-12-year-old children.

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1
Department of General Practice, Room FF 305, Erasmus MC-University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

Abstract

BACKGROUND:

Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and atopic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication.

STUDY OBJECTIVE:

To assess the relationship between diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination (DTP-IPV) in the first year of life and reported atopic disorders at primary school age.

METHOD:

1875 children attending Orthodox Reformed (Protestant) primary schools in the Netherlands returned questionnaires with data on vaccination status, atopic symptoms and lifetime atopic disorders (asthma, hay fever, eczema and food allergy), and possible confounders.

RESULTS:

The adjusted odds ratio of any atopic disorder (vaccinated/unvaccinated) was 1.00 (CI95%: 0.80-1.24). For asthma, hay fever, eczema and food allergy the results were respectively: 1.04 (CI95%: 0.76-1.42), 0.79 (CI95%: 0.55-1.12), 0.87 (CI95%: 0.66-1.14) and 1.13 (CI95%: 0.71-1.81).

CONCLUSION:

The DTP-IPV vaccination was not related to reported atopic disorders at primary school age.

PMID:
16368169
DOI:
10.1016/j.vaccine.2005.10.056
[Indexed for MEDLINE]
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