Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Clin Psychopharmacol. 2005 Nov;13(4):275-81.

The influence of caffeine on nicotine's discriminative stimulus, subjective, and reinforcing effects.

Author information

1
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA. perkinska@upmc.edu

Abstract

Caffeine may acutely alter the discriminative stimulus and subjective effects of nicotine, perhaps explaining the association of coffee intake with smoking status. In this study, smokers were initially trained to discriminate 20 microg/kg nicotine by nasal spray from placebo (0). Then, generalization of nicotine discrimination was tested, using both 2- and 3-choice ("novel" option) procedures, across a range of doses (0-20 microg/kg) following pretreatment with 0, 2.5, and 5.0 mg/kg caffeine p.o. Nicotine reinforcement was assessed after the end of generalization testing using a choice procedure. Caffeine pretreatment did not alter nicotine discrimination and self-administration. Caffeine and nicotine influenced some subjective and cardiovascular responses, but there were no interaction effects except for diastolic blood pressure. These results do not support the notion that caffeine acutely alters nicotine's discriminative stimulus, subjective, or reinforcing effects.

PMID:
16366757
DOI:
10.1037/1064-1297.13.4.275
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Psychological Association
    Loading ...
    Support Center