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J Am Chem Soc. 2005 Dec 28;127(51):17982-3.

pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.

Author information

1
Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield S3 7HF, United Kingdom.

Abstract

Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.

PMID:
16366531
DOI:
10.1021/ja056514l
[Indexed for MEDLINE]

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