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Chem Soc Rev. 2006 Jan;35(1):52-67. Epub 2005 Oct 26.

Biochemistry of human skin--our brain on the outside.

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1
Medical Biosciences, School of Life Sciences, University of Bradford, West Yorkshire, England, UK. dtobin@bradford.ac.uk

Abstract

The skin, our body's largest organ, is located at the interface between the external and internal environments, and so is strategically placed to provide not only a barrier against a range of noxious stressors (UV radiation, mechanical, chemical and biological insults) but also to act as the periphery's 'sensing' system. Recent developments suggest that this organ is much more critical to maintaining body homeostasis than previously thought. This tutorial review introduces the reader to some of the biochemistry that underpins the skin's enormous multi-functionality.

PMID:
16365642
DOI:
10.1039/b505793k
[Indexed for MEDLINE]
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