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Nat Rev Mol Cell Biol. 2006 Jan;7(1):63-8.

Clathrin-mediated endocytosis before fluorescent proteins.

Author information

1
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA. michael.roth@utsouthwestern.edu

Abstract

The recent technological advance of using fluorescent proteins to image endocytic protein traffic has resulted in a greater understanding of this dynamic process. However, most of the main concepts for how clathrin-mediated endocytosis functions were formulated long before intrinsically fluorescent proteins were available. These important conceptual breakthroughs came from the clever interpretation of simple observations.

PMID:
16365635
DOI:
10.1038/nrm1783
[Indexed for MEDLINE]

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